Marc Malès studied art in Paris, and after graduating he got a job at a publishing agency while at the same time, he began making comics and illustrations for publishers and magazines like Metal Hurlant. In 1981 he launched the series Jérôme Collard in Gomme, after which he collaborated on the BD Noires collection of Glénat publishers, drawing La Mort Obèse and Le Requin which featured the character Franck Weiss. In 1985, he started the series De Silence et de Sang with François Corteggiani, but left the rest of the artwork on the comic to Jean-Yves Mitton. He has illustrated comic adaptations of novels, such as Tom Sawyer by Mark Twain, Mon Oncle Jules by Guy De Maupassant, and The Gold Bug by Edgar Allen Poe. For Glénat in the 1990s he worked with Jean Dufaux on a comic biography of Ernest Hemmingway. Together with Philippe Thirault, he began the western series Thousand Faces for Les Humanoides Associés in 2001. They continued their collaboration with a comic adaptation of Thirault's novel Lucy in 2004.