After studying at an arts grammar school, Matteo Piana attended the School of Applied Industrial Arts in Milan where he received his degree in 1997. He began his career drawing for Corriere della Serra and at the Pastori studios. He joined Bonelli in 1999, where he illustrated the series Napoleone. He teamed up with writers Giovanni Gualdoni and Gabriele Clima, with whom he launched the series Amradel in 2001. In 2003, they created The Ring of the Seven Worlds.