Born in 1970, Pasquale Frisenda grew up in Milan, where he still lives today. From an early age he showed a strong passion for comics and drawing and in 1986 he enrolled in the illustration and comics course at Castello Sforzesco in Milan.

He began his career in the science fiction magazine Cyborg, published by Star Comics in 1990. He first published some illustrations, then a 50-page story entitled Tenebra written by Michele Masiero. The same year, he was invited by Ivo Milazzo to his studio in Chiavari. Frisenda then participated in the project Magico Vento (1997), a western/horror series conceived by Gianfranco Manfredi that marked a new stage in western adventure comics.

His work is highly appreciated by Sergio Bonelli and Decio Canzio: in 2005 he was entrusted with the task of drawing one of the prestigious Tex specials (the "Texoni"). The story, scripted by Mauro Boselli, was published in June 2009 under the title of Patagonia, and went on to win the Gran Guinigi at the 2009 edition of Lucca Comics&Games.

In 2013 he published his first story in the Tex series, written by Mauro Boselli and titled Il segreto del giudice Bean. In 2016 he made his debut in issue 47 of the series Le Storie, with "Sangue e ghiaccio" (script by Tito Faraci).