Francesco Trifogli was born on March 5, 1978 in Rome.
Though he attended a year at the Scuola Romana del Fumetto, he is predominantly a self-taught draftsmen and scriptwriter. He won the jury award at Lucca Comics & Games in 2009, just one year after its first publication. In 2012, he began his collaboration with Vertigo, illustrating a brief history for the volume Mystery in Space and the monthly series Hinterkind. In France, he worked with Éditions Tabou for which he wrote and drew seven erotic volumes and with Petit à Petit on the historical volume Le Havre.